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Battle of Mühlberg. Duke of Alba, commanding Spanish-Imperial forces of Charles I of Spain, defeats the troops of Schmalkaldic League.
The American Society for the Prevention of Cruelty to Animals (ASPCA) is founded in New York City by Henry Bergh.
Francisco de Orellana crosses South America from Guayaquil on the Pacific coast to the mouth of the Amazon River on the Atlantic coast.
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